Tuesday, August 5, 2025

Chemistry Crossword Puzzles [Essential Chemistry-aligned]

These crossword puzzles are intended for first-course students. Topical terms constitute the core of the word list. They come from PASCO Scientific’s
Essential Chemistry textbook. Additional terms (to fill in the grid space) lean toward science, but sometimes wander into simple mathematics, general knowledge, technology, pop culture, geography, initialisms and acronyms, Roman numerals, or randomness.

Although this kind of activity may seem too simple for high school science, I discovered that it is not. I wrote a post detailing my surprising findings: Crosswords that work in college-prep courses.

I created these puzzles for use in high school courses. Because I was using crossword creator software, I chose to build as robust a crossword as possible. The more crosses, the better. The fewer blank spaces on the grid, the better. The chemistry topic vocabulary served as the core of the word list. I added “fair-game” terms to fill the gaps. While competing crosswords might have 20-30 words with a few dozen crosses, each of these has over 100 words with over 150 word crosses.

essential CHEMISTRY Crossword Puzzles 
Core words: centi, chemical, claim, conclusion, conservation, control density electrical, energy, experiment, experimental, graduated, gram, hypothesis, inquiry, international, joule, kilo, kilogram, liter, macroscopic, mass, matter, measurement, mechanical, meniscus, meter, microscopic, milli, milliliter, natural, nuclear, objective, procedure, pseudoscience, radiant, repeatable, scientific, stone, theory, thermal, variable, volume, weight.

Core words: accuracy, average, bar, chemical, control, conversion, correlation, density, dependent, deviation, dimensional, energy, error, experiment, experimental, exponent, frequency, independent, inquiry, joule, linear, mantissa, mass, measurement, mechanical, objective, precision, pseudoscience, resolution, scientific, significant, slope, speed, standard, theory, variable, weight, whiskers.

Core words: accuracy, amount, bond, brittle, change, chemical, compound, density, dependent, distillation, distilled, ductile, element, elements, energy, formula, group, heterogeneous, homogeneous, intermolecular, intramolecular, isomers, joule, liter, macronutrients, malleable, mass, mixture, molecules, number, period, periodic, physical, precipitate, precision, pure, reaction, reactivity, scale, scientific, solution, symbol, tap, theorem, volume, weight.

Core words: absolute, adiabatic, boiling, brownian, calorie, calorimeter, calorimetry, celsius, closed, condensation, conduction, conductor, dependent, electrolysis, endothermic, energy, equilibrium, error, evaporation, exothermic, experiment, first, fusion, group, heat, insulator, isolated, isomers, joule, kelvin, kinetic, melting, molecular, open, period, phase, reaction, second, slope, solution, specific, system, temperature, thermal, thermistor, thermocouple, thermometer, vaporization, variable.

Core words: accuracy, amount, anion, binary, bond, cation, claim, covalent, diatomic, dissociation, element, energy, exothermic, experimental, exponent, family, group, ion, ionic, kilogram, malleable, mass, matter, measurement, mixture, nanotechnology, natural, network, nomenclature, period, periodic, polyatomic, precision, quaternary, slope, symbol, tap, ternary, theory, weight.

Core words: anhydride, anion, atomic, Avogadro, bond, cation, claim,  conclusion, conductor, dimensional, dissociation, element, empirical, energy, error, EV, exponent, family, formula, group, heat, hydrate, inquiry, joule, kinetic, mixture, molar, mole, molecular, nomenclature, open, period, periodic, polyatomic, reactivity, scale, significant, solution, STP, system, temperature, thermal, unit, volume, weight.

Core words: accuracy, anion, aqueous, atomic, average, balanced, bond, brownian, cation, combustion, covalent, decomposition, density, dependent, deviation, double, element, empirical, energy, equation, experiment, family, group, heat, hydrocarbon, insoluble, ion, ionic, joule, kelvin, liter, matter, mole, number, period, periodic, polymer, polymerization, precipitate, product, reactant, reaction, single, soluble, spectator, STP, synthesis, theory, unbalanced, variable, volume.

Core words: actual, adiabatic, anion, aqueous, atomic, Avogadro, bond, cation, celsius, claim, covalent, double, element, empirical, endothermic, equation, excess, exothermic, experiment, group, heat, hydrocarbon, ion, ionic, kelvin, limiting, matter, measurement, molar, mole, percent, period, phase, polymer, precipitate, precision, product, reactant, reaction, single, slope, soluble, solution, stoichiometry, STP, system, temperature, theoretical, unit.

Core words: anhydride, aqueous, atomic, Aufbau, bar, bond, combustion, configuration, covalent, energy, error, excess, excited, family, ground, halogens, Heisenberg, hund, hybridization, hydrate, ion, ionic, ionization, isotopes, level, limiting, mass, molar, mole, number, orbital, Pauli, periodic, photon, Planck, precipitate, product, quantum, radius, reactant, spectral, spectrometer, spectroscopy, spectrum, spin, stoichiometry, STP, strong, transition, unit, valence.

Core words: alloy, aromatic, atom, atomic, attraction, Aufbau, bond, covalent, crystal, diatomic, dipole, double, ductile, electron, electronegativity, energy, excited, ground, Hund, hybridization, hydrogen, intermolecular, ion, isoelectronic, isomers, lattice, level, Lewis, London, mass, metal, metallic, metalloids, monomer, network, nonmetals, octet, Pauli, photon, planck, polar, polarization, polymer, polymerization, radius, resonance, semiconductors, single, spin, strong, tension, triple, VanderWaals, VSEPR.

Core words: alloy, aqueous, atomic, bond, condensed, critical, deposition, dipole, double, electronegativity, endothermic, enthalpy, entropy, excess, excited, exothermic, first, formation, Gibbs, ground, Helmholtz, Hess, lattice, level, Lewis, limiting, mass, metallic, monomer, neutron, number, phase, polarization, polymer, reactant, reaction, second, single, spin, spontaneous, state, sublimation, thermochemical, triple, VSEPR.

Core words: absolute, alloy, atmospheric, atomic, avogadro, barometer, bond, Boyle, Charles, combined, Dalton, deposition, dipole, enthalpy, entropy, excited, first, Gibbs, ground, group, heat, ideal, ion, ionization, Lewis, mass, molecular, monomer, orbital, pascal, phase, photon, polar, polymer, pressure, radius, second, soluble, spin, spontaneous, state, stoichiometry, strong, sublimation, triple, unit, universal, vacuum, valence, volume, water.

Core words: absolute, aqueous, Beer, chromatography, colligative, colorimeter, combined, concentrated, concentration, conductivity, desalination, diffusion, dilute, dissociation, dissolution, dissolved, electrolyte, first, heat, Henry, hydration, immiscible, insoluble, miscible, molality, molarity, number, osmosis, pascal, phase, pressure, reverse, saturated, second, solubility, soluble, solute, solvation, solvent, supersaturated.

Core words: activation, anhydride, aqueous, atomic, bimolecular, bond, Boyle, catalyst, Charles, complex, Dalton, deposition, determining, dilute, electron, elementary, enzymes, first, Gibbs, heat, Henry, ideal, inhibitor, insoluble, intermediate, ion, ionic, mass, mechanism, miscible, molar, molarity, monomer, neutron, osmosis, pascal, phase, photon, Planck, polymer, pressure, reaction, second, solute, solvent, state, sublimation, unimolecular, vacuum, volume, water.

Core words: action, activation, alloy, barometer, bond, Boyle, catalyst, Charles, closed, constant, Dalton, deposition, dilute, dipole, electron, endothermic, enthalpy, entropy, enzymes, equilibrium, exothermic, expression, heat, ideal, inhibitor, insoluble, lattice, Lavoisier, LeChatelier, Lewis, miscible, molarity, monomer, pascal, physical, position, pressure, product, rate, soluble, solute, species, sublimation, universal, vacuum, volume, VSEPR, water.

Core words: acid, acidic, amphoteric, anion, aqueous, Arrhenius, base, Boyle, buffer, capacity, catalyst, Charles, closed, combined, common, complex, conjugate, constant, density, dilute, dipole, diprotic, enzymes, equivalence, equivalent, hydronium, indicator, inhibitor, Lavoisier, logarithm, Lowry, miscible, neutral, neutralization, normality, osmosis, pascal, physical, polyprotic, pressure, PSI, rate, reaction, salt, soluble, solute, solvent, species, strong, titration, trace, triprotic, vacuum, weak.

Core words: acid, acidic, amphoteric, anion, antioxidant, aqueous, Arrhenius, atomic, base,  buffer, catalyst, closed, common, complex, constant, dilute, electrochemistry, element, enzymes, equivalent, free, half, hydronium, ideal, indicator, inhibitor, ion, Lavoisier, neutral, normality, number, osmosis, oxidation, oxidizing, pascal, physical, pressure, rate, reaction, redox, reducing, reduction, soluble, solute, strong, titration, vacuum, volume, water, weak.

Core words: acidic, activity, alloy, ampere, anode, Arrhenius, base, bond, bridge, buffer, catalyst, cathode, cell, closed, common, constant, corrosion, coulomb, current, dipole, double, electrochemical, electrode, electrolysis, electrolyte, electrolytic, electromotive, electroplating, galvanic, Gibbs, ideal, Nernst, neutral, nonspontaneous, ohm, reaction, reduction, resistance, roan, single, spontaneous, stoichiometry, Teflon, triple, vacuum, volt, voltage, voltaic, VSEPR.

Core words: alpha, ampere, anode, antimatter, atm, atom, Avogadro, base, beta, binding, cathode, cell, chain, coulomb, current, dating, decay, defect, dose, emission, fission, fusion, gamma, intensity, inverse, ionization, ionizing, isotopes, law, mass, neutral, neutron, non, nucleons, ohm, oxidation, pH, positron, radiation, radioactivity, rate, redox, reduction, salt, uniform, uranium, volt, voltage, watt.

Core words: alcohol, aldehyde, alkane, alkene, alkyl, alkyne, alpha, amine, ampere, amu, aromatic, beta, binding, carbohydrates, carbonyl, carboxylic, condensation, coulomb, cracking, decay, dehydrogenation, dose, EMF, ester, ether, fission, free, functional, fusion, gamma, geometric, hydrocarbon, hydrogenation, ion, ketone, life, mass, non, ohm, optical, organic, parent, partial, petroleum, polymerization, rate, reaction, resonance, saturated, spin, structural, substitution, unsaturated, volt, watt.

Core words: active, adipose, alcohol, alkane, alkene, alkyne, amine, amino, amphipathic, chiral, complex, denatured, disaccharides, DNA, fat, gene, hydrophilic, hydrophobic, inhibitor, lipid, lipoproteins, micelle, monomer, monosaccharide, nitrogenous, nucleotide, oligosaccharides, optical, optimum, organic, peptide, phospholipid, polymer, polysaccharide, primary, protein, quaternary, RNA, simple, substrate, tertiary, transcription, translation, triglyceride.

Core words: ADP, alcohol, alkane, alkene, alkyne, alpha, amine, amino, anabolism, ATP, autotroph, buffer, calvin, catabolism, chemotroph, chiral, chlorophyll, chloroplast, diffusion, DNA, electrochemical, electron, enzymes, ester, ether, gene, glycolysis, GPU, group, heterotroph, homeostasis, isoenzymes, Krebs, LeChatelier, lipid, metabolism, monomer, NADH, NADPH, neutron, optimum, organic, oxidation, photosynthesis, phototroph, pigment, polymer, respiration, simple, soluble, spin, thermoregulation, transport, work.

Core words: acidification, amorphous, bond, carbon, claim, core, crystalline, cycle, dew, effect, energy, error, fixation, geologists, geosphere, greenhouse, group, hydrosphere, igneous, magma, mantle, mars, mass, matter, mesosphere, metamorphic, mineral, nebula, nitrogen, ozone, period, phosphorus, photodissociation, polymorphism, pressure, rock, salinity, sedimentary, silicates, slope, spin, stomata, stratosphere, tectonics, thermosphere, troposphere, volcano, volume, water, weight.

Core words: accretion, ATP, AU, background, blackbody, bond, calorie, chemosynthesis, cycle, doppler, extremophiles, frostline, group, heat, Hertzsprung, hydrothermal, igneous, intensity, interstellar, ionization, joule, kelvin, kinetic, lava, lightyear, magma, mass, mixture, nebula, number, period, photosphere, plasma, redox, rock, salinity, sedimentary, spectrometer, stomata, supernova, thermal, thermophiles, transpiration, volcano

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